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Characterizing the binding and function of TARP γ8-selective AMPA receptor modulators

α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid(AMPA)-type glutamate receptors (AMPARs) are the predominant excitatory neurotransmitter receptors in the brain, where they mediate synaptic transmission and plasticity. Excessive AMPAR activation leads to diseases such as epilepsy. AMPAR propertie...

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Foilsithe in:J Biol Chem
Main Authors: Dohrke, Jan-Niklas, Watson, Jake F., Birchall, Kristian, Greger, Ingo H.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2020
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Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7586208/
https://ncbi.nlm.nih.gov/pubmed/32747446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014135
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