Activation of ATM/Akt/CREB/eNOS Signaling Axis by Aphidicolin Increases NO Production and Vessel Relaxation in Endothelial Cells and Rat Aortas

Although DNA damage responses (DDRs) are reported to be involved in nitric oxide (NO) production in response to genotoxic stresses, the precise mechanism of DDR-mediated NO production has not been fully understood. Using a genotoxic agent aphidicolin, we investigated how DDRs regulate NO production...

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Vydáno v:Biomol Ther (Seoul)
Hlavní autoři: Park, Jung-Hyun, Cho, Du-Hyong, Hwang, Yun-Jin, Lee, Jee Young, Lee, Hyeon-Ju, Jo, Inho
Médium: Artigo
Jazyk:Inglês
Vydáno: The Korean Society of Applied Pharmacology 2020
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7585642/
https://ncbi.nlm.nih.gov/pubmed/32394671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4062/biomolther.2020.007
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