Metformin rescues Parkinson’s disease phenotypes caused by hyperactive mitochondria

Metabolic dysfunction occurs in many age-related neurodegenerative diseases, yet its role in disease etiology remains poorly understood. We recently discovered a potential causal link between the branched-chain amino acid transferase BCAT-1 and the neurodegenerative movement disorder Parkinson’s dis...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Mor, Danielle E., Sohrabi, Salman, Kaletsky, Rachel, Keyes, William, Tartici, Alp, Kalia, Vrinda, Miller, Gary W., Murphy, Coleen T.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7585014/
https://ncbi.nlm.nih.gov/pubmed/33024014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2009838117
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