Hypoxia Impairs NK Cell Cytotoxicity through SHP-1-Mediated Attenuation of STAT3 and ERK Signaling Pathways

Natural killer (NK) cells are innate immune effectors with potent antitumor activity. However, tumor cells can create an immunosuppressive microenvironment to escape immune surveillance. Although accumulating evidence indicates that microenvironmental hypoxia plays an important role in favoring tumo...

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發表在:J Immunol Res
Main Authors: Teng, Rui, Wang, Yanmeng, Lv, Nan, Zhang, Dan, Williamson, Ramone A., Lei, Lei, Chen, Ping, Lei, Li, Wang, Baiyan, Fu, Jiaqi, Liu, Xuna, He, Aili, O'Dwyer, Michael, Hu, Jinsong
格式: Artigo
語言:Inglês
出版: Hindawi 2020
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7584946/
https://ncbi.nlm.nih.gov/pubmed/33123602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/4598476
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