Hypoxia Impairs NK Cell Cytotoxicity through SHP-1-Mediated Attenuation of STAT3 and ERK Signaling Pathways

Natural killer (NK) cells are innate immune effectors with potent antitumor activity. However, tumor cells can create an immunosuppressive microenvironment to escape immune surveillance. Although accumulating evidence indicates that microenvironmental hypoxia plays an important role in favoring tumo...

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Detalhes bibliográficos
Publicado no:J Immunol Res
Main Authors: Teng, Rui, Wang, Yanmeng, Lv, Nan, Zhang, Dan, Williamson, Ramone A., Lei, Lei, Chen, Ping, Lei, Li, Wang, Baiyan, Fu, Jiaqi, Liu, Xuna, He, Aili, O'Dwyer, Michael, Hu, Jinsong
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7584946/
https://ncbi.nlm.nih.gov/pubmed/33123602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/4598476
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