Rational combination therapy for hepatocellular carcinoma with PARP1 and DNA-PK inhibitors

Understanding differences in DNA double-strand break (DSB) repair between tumor and normal tissues would provide a rationale for developing DNA repair-targeted cancer therapy. Here, using knock-in mouse models for measuring the efficiency of two DSB repair pathways, homologous recombination (HR) and...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Wang, Chen, Tang, Huanyin, Geng, Anke, Dai, Binghua, Zhang, Haiping, Sun, Xiaoxiang, Chen, Yu, Qiao, Zhibing, Zhu, Hong, Yang, Jiamei, Chen, Jiayu, He, Qizhi, Qin, Nan, Xie, Jinru, Tan, Rong, Wan, Xiaoping, Gao, Shaorong, Jiang, Ying, Sun, Fang-Lin, Mao, Zhiyong
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2020
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7584895/
https://ncbi.nlm.nih.gov/pubmed/33020270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2002917117
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