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MBIP (MAP3K12 binding inhibitory protein) drives NSCLC metastasis by JNK-dependent activation of MMPs

Metastasis is the cause for 90% of cancer-related mortalities. Identification of genetic drivers promoting dissemination of tumor cells may provide opportunities for novel therapeutic strategies. We previously reported an in vivo gain-of-function screen that identified ∼30 genes with a functional ro...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Ochieng, Joshua Kapere, Kundu, Samrat T., Bajaj, Rakhee, Rodriguez, B. Leticia, Fradette, Jared J., Gibbons, Don L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7584762/
https://ncbi.nlm.nih.gov/pubmed/32963352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-01463-0
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