TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins

Metastatic lung cancer is the leading cause of cancer-associated mortality worldwide, therefore necessitating novel approaches to identify specific genetic drivers for lung cancer progression and metastasis. We recently performed an in vivo gain-of-function genetic screen to identify driver genes of...

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Publicado no:Nat Commun
Main Authors: Kundu, Samrat T., Grzeskowiak, Caitlin L., Fradette, Jared J., Gibson, Laura A., Rodriguez, Leticia B., Creighton, Chad J., Scott, Kenneth L., Gibbons, Don L.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6048095/
https://ncbi.nlm.nih.gov/pubmed/30013069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05013-x
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