A platform incorporating trimeric antigens into self-assembling nanoparticles reveals SARS-CoV-2-spike nanoparticles to elicit substantially higher neutralizing responses than spike alone

Antigens displayed on self-assembling nanoparticles can stimulate strong immune responses and have been playing an increasingly prominent role in structure-based vaccines. However, the development of such immunogens is often complicated by inefficiencies in their production. To alleviate this issue,...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Zhang, Baoshan, Chao, Cara W., Tsybovsky, Yaroslav, Abiona, Olubukola M., Hutchinson, Geoffrey B., Moliva, Juan I., Olia, Adam S., Pegu, Amarendra, Phung, Emily, Stewart-Jones, Guillaume B. E., Verardi, Raffaello, Wang, Lingshu, Wang, Shuishu, Werner, Anne, Yang, Eun Sung, Yap, Christina, Zhou, Tongqing, Mascola, John R., Sullivan, Nancy J., Graham, Barney S., Corbett, Kizzmekia S., Kwong, Peter D.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7584627/
https://ncbi.nlm.nih.gov/pubmed/33097791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-74949-2
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