Structure-Based Design with Tag-Based Purification and In-Process Biotinylation Enable Streamlined Development of SARS-CoV-2 Spike Molecular Probes

Biotin-labeled molecular probes, comprising specific regions of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike, would be helpful in the isolation and characterization of antibodies targeting this recently emerged pathogen. Here, we design constructs incorporating an N-termina...

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Publicado no:Cell Rep
Main Authors: Zhou, Tongqing, Teng, I-Ting, Olia, Adam S., Cerutti, Gabriele, Gorman, Jason, Nazzari, Alexandra, Shi, Wei, Tsybovsky, Yaroslav, Wang, Lingshu, Wang, Shuishu, Zhang, Baoshan, Zhang, Yi, Katsamba, Phinikoula S., Petrova, Yuliya, Banach, Bailey B., Fahad, Ahmed S., Liu, Lihong, Lopez Acevedo, Sheila N., Madan, Bharat, Oliveira de Souza, Matheus, Pan, Xiaoli, Wang, Pengfei, Wolfe, Jacy R., Yin, Michael, Ho, David D., Phung, Emily, DiPiazza, Anthony, Chang, Lauren A., Abiona, Olubukola M., Corbett, Kizzmekia S., DeKosky, Brandon J., Graham, Barney S., Mascola, John R., Misasi, John, Ruckwardt, Tracy, Sullivan, Nancy J., Shapiro, Lawrence, Kwong, Peter D.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7550166/
https://ncbi.nlm.nih.gov/pubmed/33091382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108322
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