Structure-Based Design with Tag-Based Purification and In-Process Biotinylation Enable Streamlined Development of SARS-CoV-2 Spike Molecular Probes

Biotin-labeled molecular probes, comprising specific regions of the SARS-CoV-2 spike, would be helpful in the isolation and characterization of antibodies targeting this recently emerged pathogen. To develop such probes, we designed constructs incorporating an N-terminal purification tag, a site-spe...

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Publicado no:SSRN
Main Authors: Zhou, Tongqing, Teng, I-Ting, Olia, Adam S., Cerutti, Gabriele, Gorman, Jason, Nazzari, Alexandra, Shi, Wei, Tsybovsky, Yaroslav, Wang, Lingshu, Wang, Shuishu, Zhang, Baoshan, Zhang, Yi, Katsamba, Phinikoula S., Petrova, Yuliya, Banach, Bailey B., Fahad, Ahmed S., Liu, Lihong, Acevedo, Sheila N. Lopez, Madan, Bharat, de Souza, Matheus Olivera, Pan, Xiaoli, Wang, Pengfei, Wolfe, Jacy R., Yin, Michael, Ho, David D., Phung, Emily, DiPiazza, Anthony, Chang, Lauren, Abiona, Olubukula, Corbett, Kizzmekia S., DeKosky, Brandon J., Graham, Barney S., Mascola, John R., Misasi, John, Ruckwardt, Tracy, Sullivan, Nancy J., Shapiro, Lawrence, Kwong, Peter D.
Formato: Artigo
Idioma:Inglês
Publicado em: Social Science Electronic Publishing 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7385481/
https://ncbi.nlm.nih.gov/pubmed/32742241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2139/ssrn.3639618
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