Survey of ex vivo drug combination effects in chronic lymphocytic leukemia reveals synergistic drug effects and genetic dependencies

Drug combinations that target critical pathways are a mainstay of cancer care. To improve current approaches to combination treatment of chronic lymphocytic leukemia (CLL) and gain insights into the underlying biology, we studied the effect of 352 drug combination pairs in multiple concentrations by...

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Detalhes bibliográficos
Publicado no:Leukemia
Main Authors: Lukas, Marina, Velten, Britta, Sellner, Leopold, Tomska, Katarzyna, Hüellein, Jennifer, Walther, Tatjana, Wagner, Lena, Muley, Carolin, Wu, Bian, Oleś, Małgorzata, Dietrich, Sascha, Jethwa, Alexander, Bohnenberger, Hanibal, Lu, Junyan, Huber, Wolfgang, Zenz, Thorsten
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7584477/
https://ncbi.nlm.nih.gov/pubmed/32404973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-020-0846-5
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