The DNA methylome of human sperm is distinct from blood with little evidence for tissue-consistent obesity associations

Epidemiological research suggests that paternal obesity may increase the risk of fathering small for gestational age offspring. Studies in non-human mammals indicate that such associations could be mediated by DNA methylation changes in spermatozoa that influence offspring development in utero. Huma...

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Vydáno v:PLoS Genet
Hlavní autoři: Åsenius, Fredrika, Gorrie-Stone, Tyler J., Brew, Ama, Panchbhaya, Yasmin, Williamson, Elizabeth, Schalkwyk, Leonard C., Rakyan, Vardhman K., Holland, Michelle L., Marzi, Sarah J., Williams, David J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2020
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7584170/
https://ncbi.nlm.nih.gov/pubmed/33048947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009035
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