YB-1 Interferes with TNFα–TNFR Binding and Modulates Progranulin-Mediated Inhibition of TNFα Signaling

Inflammation and an influx of macrophages are common elements in many diseases. Among pro-inflammatory cytokines, tumor necrosis factor α (TNFα) plays a central role by amplifying the cytokine network. Progranulin (PGRN) is a growth factor that binds to TNF receptors and interferes with TNFα-mediate...

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Publicat a:Int J Mol Sci
Autors principals: Hessman, Christopher L., Hildebrandt, Josephine, Shah, Aneri, Brandt, Sabine, Bock, Antonia, Frye, Björn C., Raffetseder, Ute, Geffers, Robert, Brunner-Weinzierl, Monika C., Isermann, Berend, Mertens, Peter R., Lindquist, Jonathan A.
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7583764/
https://ncbi.nlm.nih.gov/pubmed/32992926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21197076
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