Senolytic CAR T cells reverse senescence-associated pathologies

Cellular senescence is characterized by stable cell cycle arrest and a secretory program that modulates the tissue microenvironment(1,2). Physiologically, senescence serves as a tumor suppressive mechanism that prevents the expansion of premalignant cells(3,4) and plays a beneficial role in wound he...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Nature
Main Authors: Amor, Corina, Feucht, Judith, Leibold, Josef, Ho, Yu-Jui, Zhu, Changyu, Alonso-Curbelo, Direna, Mansilla-Soto, Jorge, Boyer, Jacob A., Li, Xiang, Giavridis, Theodoros, Kulick, Amanda, Houlihan, Shauna, Peerschke, Ellinor, Friedman, Scott L., Ponomarev, Vladimir, Piersigilli, Alessandra, Sadelain, Michel, Lowe, Scott W
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7583560/
https://ncbi.nlm.nih.gov/pubmed/32555459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2403-9
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki