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Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency
Chimeric antigen receptors (CARs) are synthetic receptors that target and reprogram T cells to acquire augmented antitumor properties(1). CD19-specific CARs that comprise CD28 and CD3ζ signaling motifs(2) have induced remarkable responses in patients with refractory leukemia(3-5) and lymphoma(6) and...
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| Publicado no: | Nat Med |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6532069/ https://ncbi.nlm.nih.gov/pubmed/30559421 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-018-0290-5 |
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