Hepatocyte-intrinsic type I interferon signaling reprograms metabolism and reveals a novel compensatory mechanism of the tryptophan-kynurenine pathway in viral hepatitis

The liver is a central regulator of metabolic homeostasis and serum metabolite levels. Hepatocytes are the functional units of the liver parenchyma and not only responsible for turnover of biomolecules but also act as central immune signaling platforms. Hepatotropic viruses infect liver tissue, resu...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Lercher, Alexander, Popa, Alexandra M., Viczenczova, Csilla, Kosack, Lindsay, Klavins, Kristaps, Agerer, Benedikt, Opitz, Christiane A., Lanz, Tobias V., Platten, Michael, Bergthaler, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7580883/
https://ncbi.nlm.nih.gov/pubmed/33045014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008973
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