Synthesis, in vitro inhibitory activity, kinetic study and molecular docking of novel N-alkyl–deoxynojirimycin derivatives as potential α-glucosidase inhibitors

A series of novel N-alkyl-1-deoxynojirimycin derivatives 25 ∼ 44 were synthesised and evaluated for their in vitro α-glucosidase inhibitory activity to develop α-glucosidase inhibitors with high activity. All twenty compounds exhibited α-glucosidase inhibitory activity with IC(50) values ranging fro...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Lin, Ping, Zeng, Jia-Cheng, Chen, Ji-Guang, Nie, Xu-Liang, Yuan, En, Wang, Xiao-Qiang, Peng, Da-Yong, Yin, Zhong-Ping
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7580737/
https://ncbi.nlm.nih.gov/pubmed/33003963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2020.1826941
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