Novel C-2 Symmetric Molecules as α-Glucosidase and α-Amylase Inhibitors: Design, Synthesis, Kinetic Evaluation, Molecular Docking and Pharmacokinetics

A series of symmetrical salicylaldehyde-bishydrazine azo molecules, 5a–5h, have been synthesized, characterized by (1)H-NMR and (13)C-NMR, and evaluated for their in vitro α-glucosidase and α-amylase inhibitory activities. All the synthesized compounds efficiently inhibited both enzymes. Compound 5g...

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Vydáno v:Molecules
Hlavní autoři: Shahzad, Danish, Saeed, Aamer, Larik, Fayaz Ali, Channar, Pervaiz Ali, Abbas, Qamar, Alajmi, Mohamed F., Arshad, M. Ifzan, Erben, Mauricio F., Hassan, Mubashir, Raza, Hussain, Seo, Sung-Yum, El-Seedi, Hesham R.
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6515238/
https://ncbi.nlm.nih.gov/pubmed/30999646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24081511
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