Drug-1,3,4-Thiadiazole Conjugates as Novel Mixed-Type Inhibitors of Acetylcholinesterase: Synthesis, Molecular Docking, Pharmacokinetics, and ADMET Evaluation

A small library of new drug-1,3,4-thiazidazole hybrid compounds (3a–3i) was synthesized, characterized, and assessed for their acetyl cholinesterase enzyme (AChE) inhibitory and free radical scavenging activities. The newly synthesized derivatives showed promising activities against AChE, especially...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Ujan, Rabail, Saeed, Aamer, Channar, Pervaiz Ali, Larik, Fayaz Ali, Abbas, Qamar, Alajmi, Mohamed F., El-Seedi, Hesham R., Rind, Mahboob Ali, Hassan, Mubashir, Raza, Hussain, Seo, Sung-Yum
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6429202/
https://ncbi.nlm.nih.gov/pubmed/30823444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24050860
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