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Synthesis, α-glucosidase inhibition and molecular docking studies of novel thiazolidine-2,4-dione or rhodanine derivatives

A series of novel thiazolidine-2,4-dione or rhodanine derivatives (5a–5k, 6a–6k) were synthesized and evaluated for their α-glucosidase inhibitory activity. The majority of compounds exhibited potent inhibitory activity in the range of 5.44 ± 0.13 to 50.45 ± 0.39 μM, when compared to the standard dr...

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Publicat a:Medchemcomm
Autors principals: Wang, Guang-cheng, Peng, Ya-ping, Xie, Zhen-zhen, Wang, Jing, Chen, Ming
Format: Artigo
Idioma:Inglês
Publicat: Royal Society of Chemistry 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072357/
https://ncbi.nlm.nih.gov/pubmed/30108859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7md00173h
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