Phosphodiesterase 2A2 regulates mitochondria clearance through Parkin-dependent mitophagy

Programmed degradation of mitochondria by mitophagy, an essential process to maintain mitochondrial homeostasis, is not completely understood. Here we uncover a regulatory process that controls mitophagy and involves the cAMP-degrading enzyme phosphodiesterase 2A2 (PDE2A2). We find that PDE2A2 is pa...

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Pubblicato in:Commun Biol
Autori principali: Lobo, Miguel J., Reverte-Salisa, Laia, Chao, Ying-Chi, Koschinski, Andreas, Gesellchen, Frank, Subramaniam, Gunasekaran, Jiang, He, Pace, Samuel, Larcom, Natasha, Paolocci, Ester, Pfeifer, Alexander, Zanivan, Sara, Zaccolo, Manuela
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7578833/
https://ncbi.nlm.nih.gov/pubmed/33087821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01311-7
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