CIC Is a Mediator of the ERK1/2-DUSP6 Negative Feedback Loop

DUSP6 functions as an important negative feedback component of the MAPK/ERK signaling pathway. Although DUSP6 expression is tightly regulated by ERK1/2 signaling, the molecular mechanism of this regulation remains partially understood. In this work, we show that the transcriptional repressor CIC fun...

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Publicado no:iScience
Main Authors: Ren, Yibo, Ouyang, Zhenlin, Hou, Zhanwu, Yan, Yuwei, Zhi, Zhe, Shi, Mengjin, Du, Mengtao, Liu, Huadong, Wen, Yurong, Shao, Yongping
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7578760/
https://ncbi.nlm.nih.gov/pubmed/33103082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101635
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