ERK-mediated phosphorylation regulates SOX10 sumoylation and targets expression in mutant BRAF melanoma

In human mutant BRAF melanoma cells, the stemness transcription factor FOXD3 is rapidly induced by inhibition of ERK1/2 signaling and mediates adaptive resistance to RAF inhibitors. However, the mechanism underlying ERK signaling control of FOXD3 expression remains unknown. Here we show that SOX10 i...

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Publicado no:Nat Commun
Main Authors: Han, Shujun, Ren, Yibo, He, Wangxiao, Liu, Huadong, Zhi, Zhe, Zhu, Xinliang, Yang, Tielin, Rong, Yu, Ma, Bohan, Purwin, Timothy J., Ouyang, Zhenlin, Li, Caixia, Wang, Xun, Wang, Xueqiang, Yang, Huizi, Zheng, Yan, Aplin, Andrew E., Liu, Jiankang, Shao, Yongping
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5750221/
https://ncbi.nlm.nih.gov/pubmed/29295999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02354-x
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