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Hit-to-lead optimization of novel benzimidazole phenylacetamides as broad spectrum trypanosomacides

Trypanosoma cruzi and Trypanosoma brucei are the parasitic causative agents of Chagas disease and human African trypanosomiasis (HAT), respectively. The drugs currently used to treat these diseases are not efficacious against all stages and/or parasite sub-species, often displaying side effects. Her...

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Detalhes bibliográficos
Publicado no:RSC Med Chem
Main Authors: McNamara, Nicole, Rahmani, Raphael, Sykes, Melissa L., Avery, Vicky M., Baell, Jonathan
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7578707/
https://ncbi.nlm.nih.gov/pubmed/33479668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0md00058b
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