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TGF-β1 is a regulator of the pyruvate dehydrogenase complex in fibroblasts
TGF-β1 reprograms metabolism in renal fibroblasts, inducing a switch from oxidative phosphorylation to aerobic glycolysis. However, molecular events underpinning this are unknown. Here we identify that TGF-β1 downregulates acetyl-CoA biosynthesis via regulation of the pyruvate dehydrogenase complex...
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| Veröffentlicht in: | Sci Rep |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7578649/ https://ncbi.nlm.nih.gov/pubmed/33087819 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-74919-8 |
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