MMP9/RAGE pathway overactivation mediates redox dysregulation and neuroinflammation, leading to inhibitory/excitatory imbalance: a reverse translation study in schizophrenia patients

Various mechanisms involved in schizophrenia pathophysiology, such as dopamine dysregulation, glutamate/NMDA receptor dysfunction, neuroinflammation or redox imbalance, all appear to converge towards an oxidative stress “hub” affecting parvalbumine interneurones (PVI) and their perineuronal nets (PN...

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Pubblicato in:Mol Psychiatry
Autori principali: Dwir, Daniella, Giangreco, Basilio, Xin, Lijing, Tenenbaum, Liliane, Cabungcal, Jan-Harry, Steullet, Pascal, Goupil, Audrey, Cleusix, Martine, Jenni, Raoul, Chtarto, Abdelwahed, Baumann, Philipp S., Klauser, Paul, Conus, Philippe, Tirouvanziam, Rabindra, Cuenod, Michel, Do, Kim Q.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7577857/
https://ncbi.nlm.nih.gov/pubmed/30911107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41380-019-0393-5
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