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Rational design of cell-permeable cyclic peptides containing a D-Pro-L-Pro motif

Cyclic peptides are capable of binding to challenging targets (e.g., proteins involved in protein-protein interactions) with high affinity and specificity, but generally cannot gain access to intracellular targets because of poor membrane permeability. In this work, we discovered a conformationally...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Wen, Jin, Liao, Hui, Stachowski, Kye, Hempfling, Jordan P., Qian, Ziqing, Yuan, Chunhua, Foster, Mark P., Pei, Dehua
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7577319/
https://ncbi.nlm.nih.gov/pubmed/33069067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2020.115711
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