Novel Antibiotics May Be Noninferior but Are They Becoming Less Effective?: a Systematic Review

Novel antibiotics approved by noninferiority trials may become less effective over time in two scenarios: (i) the treatment effect in studies of novel antibiotics may be consistently worse than studies of older antibiotics; (ii) when a decreasingly effective control arm is used in a series of noninf...

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Bibliografiset tiedot
Julkaisussa:Antimicrob Agents Chemother
Päätekijät: Bai, Anthony D., Komorowski, Adam S., Lo, Carson K. L., Tandon, Pranav, Li, Xena X., Mokashi, Vaibhav, Cvetkovic, Anna, Findlater, Aidan, Liang, Laurel, Loeb, Mark, Mertz, Dominik
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2020
Aiheet:
Clinical Therapeutics
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7577162/
https://ncbi.nlm.nih.gov/pubmed/32900680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01597-20
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