Intention-to-treat analysis may be more conservative than per protocol analysis in antibiotic non-inferiority trials: a systematic review

BACKGROUND: In non-inferiority trials, there is a concern that intention-to-treat (ITT) analysis, by including participants who did not receive the planned interventions, may bias towards making the treatment and control arms look similar and lead to mistaken claims of non-inferiority. In contrast,...

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Detalhes bibliográficos
Publicado no:BMC Med Res Methodol
Main Authors: Bai, Anthony D., Komorowski, Adam S., Lo, Carson K. L., Tandon, Pranav, Li, Xena X., Mokashi, Vaibhav, Cvetkovic, Anna, Findlater, Aidan, Liang, Laurel, Tomlinson, George, Loeb, Mark, Mertz, Dominik
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8054385/
https://ncbi.nlm.nih.gov/pubmed/33874894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12874-021-01260-7
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