In Vitro Activity of the Ultra-Broad-Spectrum Beta-Lactamase Inhibitor QPX7728 in Combination with Meropenem against Clinical Isolates of Carbapenem-Resistant Acinetobacter baumannii

QPX7728 is a recently discovered ultra-broad-spectrum beta-lactamase inhibitor (BLI) with potent inhibition of key serine and metallo-beta-lactamases. QPX7728 enhances the potency of many beta-lactams, including carbapenems, in beta-lactamase-producing Gram-negative bacteria, including Acinetobacter...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Nelson, Kirk, Rubio-Aparicio, Debora, Tsivkovski, Ruslan, Sun, Dongxu, Totrov, Maxim, Dudley, Michael, Lomovskaya, Olga
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2020
Témata:
Mechanisms of Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7577151/
https://ncbi.nlm.nih.gov/pubmed/32868334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01406-20
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