QPX7728, An Ultra-Broad-Spectrum B-Lactamase Inhibitor for Intravenous and Oral Therapy: Overview of Biochemical and Microbiological Characteristics

QPX7728 is a novel β-lactamase inhibitor (BLI) that belongs to a class of cyclic boronates. The first member of this class, vaborbactam, is a BLI in the recently approved Vabomere (meropenem-vaborbactam). In this paper we provide the overview of the biochemical, structural and microbiological studie...

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Publicat a:Front Microbiol
Autors principals: Lomovskaya, Olga, Tsivkovski, Ruslan, Sun, Dongxu, Reddy, Raja, Totrov, Maxim, Hecker, Scott, Griffith, David, Loutit, Jeffery, Dudley, Michael
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2021
Matèries:
Microbiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8287861/
https://ncbi.nlm.nih.gov/pubmed/34290688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2021.697180
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