Spectrum of Beta-Lactamase Inhibition by the Cyclic Boronate QPX7728, an Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases: Enhancement of Activity of Multiple Antibiotics against Isogenic Strains Expressing Single Beta-Lactamases

QPX7728 is an ultrabroad-spectrum boronic acid beta-lactamase inhibitor, with potent inhibition of key serine and metallo-beta-lactamases being observed in biochemical assays. Microbiological studies using characterized strains were used to provide a comprehensive characterization of the spectrum of...

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Udgivet i:Antimicrob Agents Chemother
Main Authors: Lomovskaya, Olga, Tsivkovski, Ruslan, Nelson, Kirk, Rubio-Aparicio, Debora, Sun, Dongxu, Totrov, Maxim, Dudley, Michael N.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2020
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Mechanisms of Action: Physiological Effects
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269471/
https://ncbi.nlm.nih.gov/pubmed/32229489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00212-20
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