Natural Polymorphisms in Mycobacterium tuberculosis Conferring Resistance to Delamanid in Drug-Naive Patients

Mutations in the genes of the F(420) signaling pathway of Mycobacterium tuberculosis complex, including dnn, fgd1, fbiA, fbiB, fbiC, and fbiD, can lead to delamanid resistance. We searched for such mutations among 129 M. tuberculosis strains from Asia, South America, and Africa using whole-genome se...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Reichmuth, Martina L., Hömke, Rico, Zürcher, Kathrin, Sander, Peter, Avihingsanon, Anchalee, Collantes, Jimena, Loiseau, Chloé, Borrell, Sonia, Reinhard, Miriam, Wilkinson, Robert J., Yotebieng, Marcel, Fenner, Lukas, Böttger, Erik C., Gagneux, Sebastien, Egger, Matthias, Keller, Peter M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Susceptibility
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7577131/
https://ncbi.nlm.nih.gov/pubmed/32868333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00513-20
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