HIV Coinfection Is Associated with Low-Fitness rpoB Variants in Rifampicin-Resistant Mycobacterium tuberculosis

We analyzed 312 drug-resistant genomes of Mycobacterium tuberculosis isolates collected from HIV-coinfected and HIV-negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant M. tuberculosis strains isolated from HIV-coinfected patients carried dispr...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Loiseau, Chloé, Brites, Daniela, Reinhard, Miriam, Zürcher, Kathrin, Borrell, Sonia, Ballif, Marie, Fenner, Lukas, Cox, Helen, Rutaihwa, Liliana K., Wilkinson, Robert J., Yotebieng, Marcel, Carter, E. Jane, Abimiku, Alash'le, Marcy, Olivier, Gotuzzo, Eduardo, Avihingsanon, Anchalee, Zetola, Nicola, Doulla, Basra, Böttger, Erik C., Egger, Matthias, Gagneux, Sebastien
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Epidemiology and Surveillance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7508592/
https://ncbi.nlm.nih.gov/pubmed/32718966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00782-20
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