Dexmedetomidine Mediates Neuroglobin Up-Regulation and Alleviates the Hypoxia/Reoxygenation Injury by Inhibiting Neuronal Apoptosis in Developing Rats

BACKGROUND: Exploring the effective therapy for neonatal hypoxic-ischemic brain injury is an important goal. This study was designed to investigate how dexmedetomidine (DEX) contribute to hypoxic brain injury. METHODS: Developing Sprague-Dawley rat models of hypoxia/reoxygenation (H/R) injury were c...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Gao, Yan, Zhang, Yongfang, Dong, Yunxia, Wu, Xiuying, Liu, Hongtao
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7577010/
https://ncbi.nlm.nih.gov/pubmed/33117159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.555532
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