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Non-Transcriptional and Translational Function of Canonical NF-κB Signaling in Activating ERK1/2 in IL-1β-Induced COX-2 Expression in Synovial Fibroblasts
The pro-inflammatory cytokine interleukin 1β (IL-1β) induces the synthesis of prostaglandin E(2) by upregulating cyclooxygenase-2 (COX-2) in the synovial tissue of individuals with autoimmune diseases, such as rheumatoid arthritis (RA). IL-1β-mediated stimulation of NF-κB and MAPK signaling is impor...
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| 出版年: | Front Immunol |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Frontiers Media S.A.
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7576893/ https://ncbi.nlm.nih.gov/pubmed/33117381 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.579266 |
| タグ: |
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