Non-Transcriptional and Translational Function of Canonical NF-κB Signaling in Activating ERK1/2 in IL-1β-Induced COX-2 Expression in Synovial Fibroblasts

The pro-inflammatory cytokine interleukin 1β (IL-1β) induces the synthesis of prostaglandin E(2) by upregulating cyclooxygenase-2 (COX-2) in the synovial tissue of individuals with autoimmune diseases, such as rheumatoid arthritis (RA). IL-1β-mediated stimulation of NF-κB and MAPK signaling is impor...

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Vydáno v:Front Immunol
Hlavní autoři: Nakano, Rei, Kitanaka, Taku, Namba, Shinichi, Kitanaka, Nanako, Suwabe, Yoko, Konno, Tadayoshi, Yamazaki, Jun, Nakayama, Tomohiro, Sugiya, Hiroshi
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7576893/
https://ncbi.nlm.nih.gov/pubmed/33117381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.579266
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