CD137 agonist induces gastric cancer cell apoptosis by enhancing the functions of CD8(+) T cells via NF-κB signaling

BACKGROUND: CD137 is a target for tumor immunotherapy. However, the role of CD137 in gastric cancer (GC), especially in inducing GC cell apoptosis, has not been studied. METHODS: Foxp3(+) and CD8(+) T cells in GCs were investigated using immunohistochemistry (IHC). CD137 expression in GCs was detect...

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Publicat a:Cancer Cell Int
Autors principals: Hu, Ben-Shun, Tang, Tian, Jia, Jun-Li, Xie, Bi-Chen, Wu, Tie-Long, Sheng, Ying-Yue, Xue, Yu-Zheng, Tang, Hua-Min
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Primary Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7576737/
https://ncbi.nlm.nih.gov/pubmed/33093811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12935-020-01605-0
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