Next-Generation HLA Sequence Analysis Uncovers Seven HLA-DQ Amino Acid Residues and Six Motifs Resistant to Childhood Type 1 Diabetes

HLA-DQA1 and -DQB1 genes have significant and potentially causal associations with autoimmune type 1 diabetes (T1D). To follow up on the earlier analysis on high-risk HLA-DQ2.5 and DQ8.1, the current analysis uncovers seven residues (αa1, α157, α196, β9, β30, β57, and β70) that are resistant to T1D...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Diabetes
Main Authors: Zhao, Lue Ping, Papadopoulos, George K., Kwok, William W., Moustakas, Antonis K., Bondinas, George P., Carlsson, Annelie, Elding Larsson, Helena, Ludvigsson, Johnny, Marcus, Claude, Samuelsson, Ulf, Wang, Ruihan, Pyo, Chul-Woo, Nelson, Wyatt C., Geraghty, Daniel E., Lernmark, Åke
Formato: Artigo
Idioma:Inglês
Publicado: American Diabetes Association 2020
Assuntos:
Genetics/Genomes/Proteomics/Metabolomics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7576571/
https://ncbi.nlm.nih.gov/pubmed/32868339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db20-0374
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares