Next-Generation HLA Sequence Analysis Uncovers Seven HLA-DQ Amino Acid Residues and Six Motifs Resistant to Childhood Type 1 Diabetes

HLA-DQA1 and -DQB1 genes have significant and potentially causal associations with autoimmune type 1 diabetes (T1D). To follow up on the earlier analysis on high-risk HLA-DQ2.5 and DQ8.1, the current analysis uncovers seven residues (αa1, α157, α196, β9, β30, β57, and β70) that are resistant to T1D...

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Dettagli Bibliografici
Pubblicato in:Diabetes
Autori principali: Zhao, Lue Ping, Papadopoulos, George K., Kwok, William W., Moustakas, Antonis K., Bondinas, George P., Carlsson, Annelie, Elding Larsson, Helena, Ludvigsson, Johnny, Marcus, Claude, Samuelsson, Ulf, Wang, Ruihan, Pyo, Chul-Woo, Nelson, Wyatt C., Geraghty, Daniel E., Lernmark, Åke
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Diabetes Association 2020
Soggetti:
Genetics/Genomes/Proteomics/Metabolomics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7576571/
https://ncbi.nlm.nih.gov/pubmed/32868339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db20-0374
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