Downregulation of PUMA underlies resistance to FGFR1 inhibitors in the stem cell leukemia/lymphoma syndrome

Resistance to molecular therapies frequently occur due to genetic changes affecting the targeted pathway. In myeloid and lymphoid leukemias/lymphomas resulting from constitutive activation of FGFR1 kinases, resistance has been shown to be due either to mutations in FGFR1 or deletions of PTEN. RNA-Se...

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Bibliographic Details
Published in:Cell Death Dis
Main Authors: Liu, Yun, Cai, Baohuan, Chong, Yating, Zhang, Hualei, Kemp, Chesley-Anne, Lu, Sumin, Chang, Chang-Sheng, Ren, Mingqiang, Cowell, John K., Hu, Tianxiang
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7576156/
https://ncbi.nlm.nih.gov/pubmed/33082322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03098-1
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