Mainstreaming germline BRCA1/2 testing in non-mucinous epithelial ovarian cancer in the North West of England

Poly(ADP-ribose) polymerase (PARP) inhibitors improve survival in BRCA-mutant high-grade serous ovarian carcinoma. As a result, germline and somatic BRCA1/2 testing has become standard practice in women diagnosed with ovarian cancer. We outline changes in testing and detection rates of germline BRCA...

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Bibliografiset tiedot
Julkaisussa:Eur J Hum Genet
Päätekijät: Flaum, Nicola, Morgan, Robert D., Burghel, George J., Bulman, Michael, Clamp, Andrew R., Hasan, Jurjees, Mitchell, Claire L., Badea, Doina, Moon, Sarah, Hogg, Martin, Hadjiyiannakis, Dennis, Clancy, Tara, Schlecht, Helene, Woodward, Emma R., Crosbie, Emma J., Edmondson, Richard J., Wallace, Andrew J., Jayson, Gordon C., Lalloo, Fiona I., Harkness, Elaine F., Evans, D. Gareth R.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Springer International Publishing 2020
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7575602/
https://ncbi.nlm.nih.gov/pubmed/32651552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41431-020-0692-y
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