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Diphthamide-deficiency syndrome: a novel human developmental disorder and ribosomopathy

We describe a novel type of ribosomopathy that is defined by deficiency in diphthamidylation of translation elongation factor 2. The ribosomopathy was identified by correlating phenotypes and biochemical properties of previously described patients with diphthamide biosynthesis gene 1 (DPH1) deficien...

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Detalhes bibliográficos
Publicado no:Eur J Hum Genet
Main Authors: Hawer, Harmen, Mendelsohn, Bryce A., Mayer, Klaus, Kung, Ann, Malhotra, Amit, Tuupanen, Sari, Schleit, Jennifer, Brinkmann, Ulrich, Schaffrath, Raffael
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7575589/
https://ncbi.nlm.nih.gov/pubmed/32576952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41431-020-0668-y
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