Importance of diphthamide modified EF2 for translational accuracy and competitive cell growth in yeast

In eukaryotes, the modification of an invariant histidine (His-699 in yeast) residue in translation elongation factor 2 (EF2) with diphthamide involves a conserved pathway encoded by the DPH1-DPH7 gene network. Diphthamide is the target for diphtheria toxin and related lethal ADP ribosylases, which...

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Bibliographic Details
Published in:PLoS One
Main Authors: Hawer, Harmen, Ütkür, Koray, Arend, Meike, Mayer, Klaus, Adrian, Lorenz, Brinkmann, Ulrich, Schaffrath, Raffael
Format: Artigo
Language:Inglês
Published: Public Library of Science 2018
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6193676/
https://ncbi.nlm.nih.gov/pubmed/30335802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0205870
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