CHIP phosphorylation by protein kinase G enhances protein quality control and attenuates cardiac ischemic injury

Proteotoxicity from insufficient clearance of misfolded/damaged proteins underlies many diseases. Carboxyl terminus of Hsc70-interacting protein (CHIP) is an important regulator of proteostasis in many cells, having E3-ligase and chaperone functions and often directing damaged proteins towards prote...

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Publicado no:Nat Commun
Main Authors: Ranek, Mark J., Oeing, Christian, Sanchez-Hodge, Rebekah, Kokkonen-Simon, Kristen M., Dillard, Danielle, Aslam, M. Imran, Rainer, Peter P., Mishra, Sumita, Dunkerly-Eyring, Brittany, Holewinski, Ronald J., Virus, Cornelia, Zhang, Huaqun, Mannion, Matthew M., Agrawal, Vineet, Hahn, Virginia, Lee, Dong I., Sasaki, Masayuki, Van Eyk, Jennifer E., Willis, Monte S., Page, Richard C., Schisler, Jonathan C., Kass, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7575552/
https://ncbi.nlm.nih.gov/pubmed/33082318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18980-x
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