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New computational protein design methods for de novo small molecule binding sites

Protein binding to small molecules is fundamental to many biological processes, yet it remains challenging to predictively design this functionality de novo. Current state-of-the-art computational design methods typically rely on existing small molecule binding sites or protein scaffolds with existi...

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Bibliografiset tiedot
Julkaisussa:PLoS Comput Biol
Päätekijät: Lucas, James E., Kortemme, Tanja
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2020
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7575090/
https://ncbi.nlm.nih.gov/pubmed/33017412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1008178
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