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GLT-1 Knockdown Inhibits Ceftriaxone-Mediated Improvements on Cognitive Deficits, and GLT-1 and xCT Expression and Activity in APP/PS1 AD Mice
OBJECTIVE: Glutamate transporter-1 (GLT-1) and system x(c)(–) mediate glutamate uptake and release, respectively. Ceftriaxone has been reported to upregulate GLT-1 expression and improve cognitive decline in APP/PS1 mice. The aim of the present study was to elucidate the role of GLT-1 in ceftriaxone...
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| Publicado no: | Front Aging Neurosci |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7574737/ https://ncbi.nlm.nih.gov/pubmed/33132901 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2020.580772 |
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