tPA Deficiency Underlies Neurovascular Coupling Dysfunction by Amyloid-β

The amyloid-β (Aβ) peptide, a key pathogenic factor in Alzheimer's disease, attenuates the increase in cerebral blood flow (CBF) evoked by neural activity (functional hyperemia), a vital homeostatic response in which NMDA receptors (NMDARs) play a role through nitric oxide, and the CBF increase...

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Bibliografski detalji
Izdano u:J Neurosci
Glavni autori: Park, Laibaik, Zhou, Joan, Koizumi, Kenzo, Wang, Gang, Anfray, Antoine, Ahn, Sung Ji, Seo, James, Zhou, Ping, Zhao, Lingzhi, Paul, Steven, Anrather, Josef, Iadecola, Costantino
Format: Artigo
Jezik:Inglês
Izdano: Society for Neuroscience 2020
Teme:
Research Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7574658/
https://ncbi.nlm.nih.gov/pubmed/32928888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1140-20.2020
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