Identification of fetal unmodified and 5-hydroxymethylated CG sites in maternal cell-free DNA for non-invasive prenatal testing

BACKGROUND: Massively parallel sequencing of maternal cell-free DNA (cfDNA) is widely used to test fetal genetic abnormalities in non-invasive prenatal testing (NIPT). However, sequencing-based approaches are still of high cost. Building upon previous knowledge that placenta, the main source of feta...

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Détails bibliographiques
Publié dans:Clin Epigenetics
Auteurs principaux: Gordevičius, Juozas, Narmontė, Milda, Gibas, Povilas, Kvederavičiūtė, Kotryna, Tomkutė, Vita, Paluoja, Priit, Krjutškov, Kaarel, Salumets, Andres, Kriukienė, Edita
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2020
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7574562/
https://ncbi.nlm.nih.gov/pubmed/33081811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-020-00938-x
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