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Engineering a Methyllysine Reader with Photoactive Amino Acid in Mammalian Cells()
Methyllysine sites in proteins are recognized by an array of reader domains that mediate protein-protein interactions for controlling cellular processes. Herein, we engineer a chromodomain, an essential methyllysine reader, to carry 4-azido-L-phenylalanine (AzF) via amber suppressor mutagenesis and...
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| 發表在: | Chem Commun (Camb) |
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| Main Authors: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7573786/ https://ncbi.nlm.nih.gov/pubmed/32926023 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0cc03814h |
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