Evaluation of the Immunogenicity and Protective Efficacy of an Enterotoxigenic Escherichia coli CFA/I Adhesin–Heat-Labile Toxin Chimera

Recent efforts to develop an enterotoxigenic Escherichia coli (ETEC) vaccine have focused on the antigenically conserved tip adhesins of colonization factors. We showed previously that intranasal immunization with dsc(19)CfaE, a soluble variant of the in cis donor strand-complemented tip adhesin of...

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Udgivet i:Infect Immun
Main Authors: O'Dowd, Aisling, Maciel, Milton, Poole, Steven T., Jobling, Michael G., Rollenhagen, Julianne E., Woods, Colleen M., Sincock, Stephanie A., McVeigh, Annette L., Gregory, Michael J., Maves, Ryan C., Prouty, Michael G., Holmes, Randall K., Savarino, Stephen J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2020
Fag:
Microbial Immunity and Vaccines
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7573451/
https://ncbi.nlm.nih.gov/pubmed/32839188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00252-20
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